Pathomorphological Markers of the Explosive Wave Action on Human Brain

Introduction. The increased attention of researchers to an explosive trauma around the world is associated with a constant renewal of military weapons and a significant increase in terrorist activities using explosive devices. Explosive wave is a well known damaging factor of explosion. The most sensitive to the action of explosive wave in the human body are the head brain, lungs, intestines, urine bladder. The severity of damage to these organs depends on the distance from the explosion epicenter to the object, the power of the explosion, presence of barriers, parameters of the body position, and the presence of protective clothing. One of the places where a shock wave acts, in human tissues and organs, is the vascular endothelial barrier, which suffers the greatest damage in the head brain and lungs. The objective of the study was to determine the pathomorphological changes of the head brain followed the action of explosive wav

Hubungan Karakteristik Dan Perilaku Masyarakat Dengan Kejadian Malaria Di Rumah Sakit Sinar Kasih Tentena Kabupaten Poso Provinsi Sulawesi Tengah

:Malaria is disease causedby protozoan parasites of genus plasmodium. That are transmitted through the bite of the Anopheles and still a community health problem in Indonesia.The objective of this study was to know the relationship characteristics between and behavior of society with the incidence of malaria in Sinar Kasih Tentena Hospital. This research using by cross sectional method.Collecting of Data by using observation and questionnaire as the respondent houses. The sampling method is purposive sampling.Total of sample 62 respondents consists of malaria Plasmodium falciparum and Plasmodium vivax. Univariate analysis using by SPSS and bivariate analysis were processed by chi-square test for probability of 95% (α=0,05). The result showed people's characteristics: age (p=0.349), education (p=0.840), occupation (p=0.145) and social behavior: costum activity outside the home at the night (p=0.003), use mosquito nets habits(p=0.000), use of anti mosquito (p=0.007). Conclusions: there was no relationship between the characteristics of people with incidence of malaria, and there was a relationship between the behavior of people with malaria incidence. Suggestion: Medical worker be expected for more active in counseling to society around district, then the society itself for more motivated to using mosquito nets habits and protective clothing like jacket or using anti mosquito that used on skin. They have to use it before leaving their home at night. Then, one more important thing is awareness to terminate the mosquitos nests (place to live and multiply)

Pengaruh Bahan Mineral Dan Air Laut Terhadap Sifat Fisika – Kimia Tanah Dan Pertumbuhan Padi Di Lahan Gambut Dataran Tinggi

Objective of this research is studied of mineral substances and sea water effect on physico-chemicalproperties of highland peat. It was conducted at highland peat in Hutabagasan, Dolok SanggulSub – district Humbang Hasundutan Regency, North Sumatera. This research used non – factorialrandomized block design with four treatments those are G0 (Control), G1 (5kgs Volcanic sand), G2(5kgs Volcanic sand + 2,5L Sea water), G3 (5kgs Volcanic sand + 1kg Zeolite + 2,5L Sea water)and 3 replicants. The results showed that application of Volcanic sand (G1) significantly increasingon soil base saturation. Addition of sea water with volcanic sand and volcanic sand + zeolite (G2dan G3) significantly increasing on soil electric conductivity, exchangeable sodium, exchangeablemagnesium but decrease exchangeable calsium, and base saturation. Zeolite has a role as buffer ofsoil pH, soil electric conductivity and bulk dencity. The Application of all ameliorants have notpositive influence on the growth of rice plant and even decrease number of vegetative tillers

Partitioning of trace elements in a entrained flow IGCC plant: Influence of selected operational conditions

The partitioning of trace elements and the influence of the feed conditions (50:50 coal/pet-coke feed blend and limestone addition) was investigated in this study. To this end feed fuel, fly ash and slag samples were collected under different operational conditions at the 335 MW Puertollano IGCC power plant (Spain) and subsequently analysed. The partitioning of elements in this IGCC plant may be summarised as follows: (a) high volatile elements (70–>99% in gas phase): Hg, Br, I, Cl and S; (b) moderately volatile elements (up to 40% in gas phase and 60% in fly ash): As, Sb, Se, B, F, Cd, Tl, Zn and Sn; (c) elements with high condensation potential: (>90% in fly ash): Pb, Ge, Ga and Bi; (d) elements enriched similarly in fly ash and slag 30–60% in fly ash: Cu, W, (P), Mo, Ni and Na; and (e) low volatile elements (>70% in slag): Cs, Rb, Co, K, Cr, V, Nb, Be, Hf, Ta, Fe, U, Ti, Al, Si, Y, Sr, Th, Zr, Mg, Ba, Mn, REEs, Ca and Li. The volatility of As, Sb, and Tl and the slagging of S, B, Cl, Cd and low volatile elements are highly influenced by the fuel geochemistry and limestone dosages, respectively

Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein

<p>Abstract</p> <p>Background</p> <p>The promyelocytic leukemia (PML) protein participates in a number of cellular processes, including transcription regulation, apoptosis, differentiation, virus defense and genome maintenance. This protein is structurally organized into a tripartite motif (TRIM) at its N-terminus, a nuclear localization signal (NLS) at its central region and a C-terminus that varies between alternatively spliced isoforms. Most PML splice variants target the nucleus where they define sub-nuclear compartments termed PML nuclear bodies (PML NBs). However, PML variants that lack the NLS are also expressed, suggesting the existence of PML isoforms with cytoplasmic functions. In the present study we expressed PML isoforms with a mutated NLS in U2OS cells to identify potential cytoplasmic compartments targeted by this protein.</p> <p>Results</p> <p>Expression of NLS mutated PML isoforms in U2OS cells revealed that PML I targets early endosomes, PML II targets the inner nuclear membrane (partially due to an extra NLS at its C-terminus), and PML III, IV and V target late endosomes/lysosomes. Clustering of PML at all of these subcellular locations depended on a functional TRIM domain.</p> <p>Conclusions</p> <p>This study demonstrates the capacity of PML to form macromolecular protein assemblies at several different subcellular sites. Further, it emphasizes a role of the variable C-terminus in subcellular target selection and a general role of the N-terminal TRIM domain in promoting protein clustering.</p

A Scalable Middleware Solution for Advanced Wide Area Web Services

To alleviate scalability problems in the Web, many researchers concentrate on how to incorporate advanced caching and replication techniques. Many solutions incorporate object-based techniques. In particular, Web resources are considered as distributed objects offering a well-defined interface. We argue that most proposals ignore two important aspects. First, there is little discussion on what kind of coherence should be provided. Proposing specific caching or replication solutions makes sense only if we know what coherence model they should implement. Second, most proposals treat all Web resources alike. Such a one-size-fits-all approach will never work in a wide-area system. We propose a solution in which Web resources are encapsulated in physically distributed shared objects. Each object should encapsulate not only state and operations, but also the policy by which its state is distributed, cached, replicated, migrated, etc

Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres

The activation of a telomere maintenance mechanism is required for cancer development in humans. While most tumors achieve this by expressing the enzyme telomerase, a fraction (5–15%) employs a recombination-based mechanism termed alternative lengthening of telomeres (ALT). Here we show that loss of the single-stranded DNA-binding protein replication protein A (RPA) in human ALT cells, but not in telomerase-positive cells, causes increased exposure of single-stranded G-rich telomeric DNA, cell cycle arrest in G2/M phase, accumulation of single-stranded telomeric DNA within ALT-associated PML bodies (APBs), and formation of telomeric aggregates at the ends of metaphase chromosomes. This study demonstrates differences between ALT cells and telomerase-positive cells in the requirement for RPA in telomere processing and implicates the ALT mechanism in tumor cells as a possible therapeutic target

Are European Blue Economy ambitions in conflict with European environmental visions?

We report the outcomes of a comprehensive study of the potential consequences of the implementation of the EU Maritime Spatial Planning Directive (MSPD) in Danish waters. The analyses are anchored in a framework developed in support of data-driven Ecosystem-Based Maritime Spatial Planning. The data for the models include not only human stressors but also information on the distribution of ecosystem components ranging from planktonic communities over benthic communities to fish, seabirds and marine mammals. We have established a baseline, based on state-of-the-art data sets, with respect to combined effects upon ecosystem components. Future scenarios for the developments in human stressors were estimated for 2030 and 2050 based on information on existing policies, strategies and plans and were compared to the baseline. In addition, we developed a scenario for implementation of the Marine Strategy Framework Directive (MSFD), i.e. working towards meeting the objectives of Good Environmental Status. Our results indicate that (1) combined human stressors will possibly increase in 2030 and 2050 compared to the baseline, (2) increased combined human stressors are likely to lead to a worsening of the environmental and ecological status sensu the Marine Strategy Framework Directive and the Water Framework Directive (WFD), and (3) the MSPD implementation process appears to conflict with the MSFD and WFD objectives. Accordingly, we are sceptical of claims of an untapped potential for Blue Growth in Danish marine waters.publishedVersio